The Myopia Pandemic

Aug. 28, 2015

By Medical Discovery News

The Myopia Pandemic

You’ve probably heard of pandemics – the plague, influenza, HIV – but you might not have seen coverage of the growing myopia pandemic. Before you consider bathing in sanitizer, you should know that myopia isn’t contagious. Another word for it is nearsightedness.

Myopia is a condition in which close objects are seen clearly but distant objects are blurred due to the elongation of the eye or too much curvature of the cornea. This causes light entering the eye focusing in front of the retina rather than on it. Myopia is different than hyperopia, which is the kind of nearsightedness that comes from growing older. In fact, the myopia pandemic is primarily affecting young people.

It currently affects 90 percent of the young adults in China, although 60 years ago it was 10-20 percent. In the United States and Europe it affects about half of all young adults, double what it was 50 years ago. Seoul has the highest incidence: 96.5 percent of young people in South Korea’s capital have myopia. An estimated 2.5 billion people will experience myopia by 2020.

Vision issues can be corrected with glasses, contact lenses, or surgery, but none of those fix the underlying defect. Eye elongation can stretch and thin parts of the inner eye, which can increase the risk of retinal detachment, glaucoma, cataracts, and even blindness.

Genetic causes have been discounted, so this rapid change has to come from something in the environment. More than 400 years ago, Johannes Kepler, an astronomer and expert in optics, wrote that his intense studying led to nearsightedness. Today, students are not only studying a great deal but are also spending much of their time with cell phones, tablets, computers, and video games, primarily indoors.

Intense periods of reading and studying were disproved as a cause of myopia during a study in 2000. Seven years later, scientists from Ohio State University followed more than 500 eight- and nine-year-olds with healthy vision and tracked the time they spent outdoors. After five years, 20 percent had developed myopia, which correlated to the time they spent indoors. This was confirmed one year later, when scientists in Australia studied 4,000 students and also reported that the amount of time spent indoors was the important factor.

It’s probably because the retina of the eye produces and releases more dopamine, a neurotransmitter, during the day to signal the eye to switch from night to daytime vision. Indoor light disrupts this cycle, affecting eye development. Only 30 percent of Australian children who spent three or more hours outside each day had myopia. A systematic review paper aggregated previous studies and concluded that each hour of each week spent outside reduces a child’s chance of developing myopia by 2 percent.

Researchers are examining possible ways to control the development of myopia, such as altering the way contact lenses focus light, producing eye drops that block neurotransmitter release, and using artificial lights like those used to treat seasonal affective disorder, also known as winter depression. Of course, having children play or simply be outside seems the best option, and it has other health benefits too.

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Cancer Goggles

June 6, 2014

By Medical Discovery News

Cutting people open and sewing them back up for a living is a pretty stressful occupation to begin with, but some surgeons have tougher jobs than others. Cancer surgeons are charged with removing all tumor cells on the first try. But tumor growth can be irregular and it can be hard to distinguish cancer cells from normal cells during an operation. Imaging techniques like MRIs and CT scans can give surgeons a road map to the tumor, but they offer only limited help once an incision has been made.

This is because these images are merely snapshots – a single frame and dimension. Even three-dimensional images can only be viewed one frame at a time. In addition, the inside of the body is dynamic and it takes a skilled surgeon to understand the orientation of tissues and the precise margins where tumor tissue ends and regular tissue begins. 

Because of this challenge, surgeons often have to remove healthy tissue to be sure all tumor cells are gone. This requires a special step: staining the removed tissue then looking at it under a microscope to identify the cells. The surgeon wants to be sure a margin of healthy tissue is removed so no tumor cells remain.

If tumor cells remain, they will grow and second operation may be necessary to remove more cancerous tissue. Again, the removal of additional healthy tissue will be necessary. But what if a surgeon could distinguish cancer cells from normal cells during surgery? It seems impossible. Each cell is microscopic, thousandths of a millimeter. Just observing cells takes special staining and high-powered optics.

But scientists at the University of Missouri and Washington University in St. Louis are working on the impossible. They are developing cancer goggles that will allow surgeons see tumor cells right in the operating room. This new technology uses LS301, a fluorescent dye combined with a short chain of amino acids called peptide, that is only absorbed by cancer cells and glows under infrared light. This dye specifically stains cells from prostrate, colon, breast, and liver cancers among others. Patients can be injected with the dye beforehand and it will last through a procedure.

These special goggles will illuminate cancer cells with LS301 using an infrared light source. A surgeon can distinguish glowing cancer cells from normal cells and observe when they are completely removed. As a result, the surgeon would not need to remove a margin of healthy tissue to be sure all cancerous tissue is gone. This may greatly improve success rates from surgeries to remove cancerous growths. 

Currently, this technique is being perfected in veterinary surgeries to guide the removal of tumors in pets and is not yet ready for use with humans. If effective, it will be a great resource for patients undergoing tumor removal surgery in the future.

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