Chocolate on My Mind

April 10, 2015

By Medical Discovery News

Chocolate

Peanuts creator Charles Schulz once said, “All you need is love. But a little chocolate now and then doesn’t hurt.” New research shows he might be right. In one study, certain compounds in cocoa called flavanols reversed age-related memory problems.

Flavanols, found in a variety of plants, are potent antioxidants that help cells in the body deal with free radicals. Free radicals arise from normal cellular processes as well as from exposure to environmental contaminants, especially cigarette smoke. Unless your body gets rid of free radicals, they can damage proteins, lipids, and even your genetic information. You can get flavanols from tea, red wine, berries, cocoa, and chocolate. Flavanols are what give cocoa that strong, bitter, and pungent taste. Cocoa is processed through fermentation, alkalization, and roasting among other methods, which can influence how much of the good flavanols are lost. Among the products made from cocoa, those with the highest levels of flavanol are cocoa powders not processed by the Dutch method, followed by unsweetened baking chocolate, dark chocolate and semi-sweet chips, then milk chocolate, and finally chocolate syrup contained the least.

In the latest study, a cocoa drink specially formulated by the Mars food company to retain flavanols was compared with another drink that contained very little flavanols. The study asked 37 randomly selected adults aged 50 to 69 to take one of the drinks. One group consumed 900 milligrams per day of flavanols and the others consumed only 10 milligrams per day for three months. Brain imaging and memory tests were administered before and after the trial.

Those who consumed the high levels of cocoa flavanols had better brain function and improved memories. Before the study, the subjects on average demonstrated the memory of a typical 60-year-old person. At the end, those who consumed more flavanols exhibited the memory capabilities more closely resembling a 30- to 40-year-old. Unfortunately, the average candy bar contains only about 40 milligrams of flavanol, so you would have to eat 23 of them a day to equal the amount of flavanol used in the study, which would lead to other health problems like obesity and diabetes.

Other studies have similarly revealed that high-flavanol cocoa beverages cause regional changes in the brain’s blood flow, suggesting that it could be used to treat vascular impairments within the brain. Flavanols have also been reported to reduce blood pressure and other factors that lead to cardiovascular disease, improve insulin sensitivity, modulate platelet activity thereby reducing the risk of blood clots, and improve the activities of the endothelial cells that line our blood vessels. The Kuna indians living on the San Blas Islands near Panama, who consume a type of cocoa rich in flavanol on a daily basis, have unusually low rates of hypertension, cardiovascular disease, cancer, and diabetes.

These studies need to be repeated with larger groups to confirm the benefits of consuming flavanols and to ensure that there are no negative effects. Still, if a cocoa beverage high in flavanols could be mass produced and marketed, we could improve human health in a very tasty way.

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Lifesaving Venom

By Medical Discovery News

Sept. 1, 2012

Reversing Cerebral Palsy

People have evolved a fear of snakes out of necessity. One bite from a venomous snake can prove fatal, so it’s ironic that a number of remarkable drugs are derived not only from poisonous snakes, but other deadly creatures as well. Researchers increasingly prize this group of animals, believing their venom holds the promise of effective treatments for major disorders ranging from high blood pressure to heart disease to cancer.

Depending on the type of poisonous snake, a bite can cause a drop in platelets and lead to uncontrollable bleeding. Or it can, like the venom of the Brazilian pit viper, incapacitate victims by causing their blood pressure to plummet. But in smaller doses these same characteristics can reverse disease.

One group of drugs, called ACE inhibitors, brings down blood pressure by decreasing chemicals that tighten blood vessels so that blood flows more smoothly. Another drug, called tirofiban, comes from the saw-scaled viper, which has venom that thins the blood and causes victims to bleed out. As a drug, it’s an anticoagulant used to dissolve blood clots in people with a minor or impending heart attack.

Another venom with similar mechanisms comes from the Malayan pit viper, except it also possesses a protein that may dissolve clots for as long as six hours after stroke symptoms start. An international study is targeting this venom’s potential to expand the three-hour window required for current drugs to be effective. Allowing people more time to get to a hospital for evaluation and treatment makes a significant difference on their prognosis.

Other deadly creatures also have lifesaving potential. Scientists are studying the fatal Deathstalker scorpion native to North Africa and the Middle East. Yet, its venom contains Chlorotoxin, which just happens to attach to cancer cells by binding strongly to a cancer-specific protein called matrix metalloproteinase-2. By fluorescently labeling Chlorotoxin, surgeons can easily identify cancer tissues and remove them. Scientists also figured out that by radioactively labeling Chlorotoxin, the toxin targets tumor cells and the radiation kills them.

Another example is Cobratoxin, which Western pharmacists began experimenting with as early as the 1930s on patients with diseases such as multiple sclerosis (MS) and asthma. More recently, a modified form of Cobratoxin has been shown to block the development of induced MS in 90 percent of lab rats. Cobratoxin seems to stimulate a molecule called interleukin 27, which slows an overactive immune response that scientists believe may be causing the disease. A related toxin molecule called Cobrotoxin has been shown in studies to impede the spread of HIV by blocking the receptors the virus uses to infect cells.

While the field of venom study has grown, researchers are concerned that negative environmental impacts on some of the threatened venomous species will limit their work. Ultimately that reduces the number of potential life saving or life changing drugs that are possible.

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